Brain Imaging
We have developed an inclusive protocol to take high-resolution brain images of children and youth with NDDs who have behaviours of concern.
Advanced magnetic resonance imaging (MRI) allows researchers to study the structure and function of the brain with high spatial resolution. However, MRI requires participants to remain still in a confined space for several minutes, making it particularly challenging for children with NDDs and behaviours of concern (BoC) to participate without sedation. As a result, this population is largely underrepresented in brain imaging research, and little is known about the neural correlates of BoC in children with NDDs.
To address this gap, we have developed an inclusive MRI protocol which combines behavioural and technical adaptations specifically designed for children and youth with NDDs who have BoC. Behavioural adaptations include preparation sessions using a mock MRI scanner which helps participants become familiar with the environment and reduce anxiety, as well as videos, children's books, and social stories to allow families to prepare in a way best suited to their children's needs and development. Technical adaptations involve optimizing MRI sequence parameters for faster, motion-insensitive image acquisition, minimizing the need for extended stillness, as well as noise-cancelling headsets and other in-scanner adaptations.
Family input played a key role in the process. Families provided information about the specific needs of each participant, allowing appointments to be tailored for maximum comfort and success. This individualized approach has led to high-quality imaging results and high rates of successful scans without the use of sedation. The resulting brain images will be analysed using advanced machine learning techniques to explore neural correlates of BoC.
Collaborators:
The PN Lab Advisory Council
Dr. Nils D. Forkert PhD, Professor, Radiology, University of Calgary
Dr. Catherine Lebel PhD, Professor, Radiology, University of Calgary